Reimbursement for Amniotic Tissue

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Topic: Amniotic Membrane

Sponsor: Integra

Updated: 01/01/2018

This FAQ addresses the following:

What is BioDOptix® and how is it used in eye care?
What CPT code describes application of BioDOptix® on the ocular surface?
Does Medicare cover placement of an amniotic tissue allograft?
What is the Medicare allowed amount for 65778?
Does Medicare pay for the supply of the amniotic tissue separately?
What does Medicare allow as a facility fee for 65778?
What is the postoperative surgical period for 65778?
How am I reimbursed for using amniotic tissue during the postoperative period of another procedure?
How is amniotic tissue reimbursed when used after refractive surgery?

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The reimbursement information is provided by Corcoran Consulting Group based on publicly available information from CMS, the AMA, and other sources. The reader is strongly encouraged to review federal and state laws, regulations, code sets, and official instructions promulgated by Medicare and other payers. This document is not an official source nor is it a complete guide on reimbursement. Although we believe this information is accurate at the time of publication, the reader is reminded that this information, including references and hyperlinks, changes over time, and may be incorrect at any time following publication.

© 2026 Corcoran Consulting Group. A Subsidiary of Medical Consulting Group, LLC. All rights reserved. No part of this publication may be reproduced or distributed in any form or by any means, or stored in a retrieval system, without the written permission of the publisher. CPT is a registered trademark of the American Medical Association.